|
rs1046282
|
ERCC1;PPP1R13L;CD3EAP
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
The haplotype ERCC2 rs3916874(G) and rs238415(C) [OR (95% CI)=1.26 (1.02-1.57), P=0.03] in block 1 and the haplotype PPP1R13L rs4803817(A), CD3EAP rs1046282(T), rs735482(C), ERCC1 rs3212980(A), rs3212964(G) [OR (95% CI)=3.56 (1.55-8.18), P=0.005] in block 3 were associated with lung cancer risk.
|
24140460 |
2013 |
|
rs1046282
|
ERCC1;PPP1R13L;CD3EAP
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
The haplotype ERCC2 rs3916874(G) and rs238415(C) [OR (95% CI)=1.26 (1.02-1.57), P=0.03] in block 1 and the haplotype PPP1R13L rs4803817(A), CD3EAP rs1046282(T), rs735482(C), ERCC1 rs3212980(A), rs3212964(G) [OR (95% CI)=3.56 (1.55-8.18), P=0.005] in block 3 were associated with lung cancer risk.
|
24140460 |
2013 |
|
rs1046282
|
ERCC1;PPP1R13L;CD3EAP
|
Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
The results of clinicopathologic analysis showed that A allele at the rs737241 locus could increase the expression level of AFP (P = .007), the rs1046282 mutation C allele could increase the AFP expression level (P = .011), rs4024 locus mutation A allele could reduce the risk of vascular invasion (P = .013), rs3212948 locus mutation T allele could reduce the differentiation of liver cancer (P = .022), rs1046282 locus C allele could reduce the DNA load of hepatitis B virus (P = .035), and rs735482 A allele could increase the tumor size in HCC (P = .037).The SNPs in rs737241 for AFP gene may correlate with the occurrence of HCC.
|
30946366 |
2019 |
|
rs1046282
|
ERCC1;PPP1R13L;CD3EAP
|
Hepatitis B
|
|
0.010 |
GeneticVariation |
BEFREE |
The results of clinicopathologic analysis showed that A allele at the rs737241 locus could increase the expression level of AFP (P = .007), the rs1046282 mutation C allele could increase the AFP expression level (P = .011), rs4024 locus mutation A allele could reduce the risk of vascular invasion (P = .013), rs3212948 locus mutation T allele could reduce the differentiation of liver cancer (P = .022), rs1046282 locus C allele could reduce the DNA load of hepatitis B virus (P = .035), and rs735482 A allele could increase the tumor size in HCC (P = .037).The SNPs in rs737241 for AFP gene may correlate with the occurrence of HCC.
|
30946366 |
2019 |
|
rs1046282
|
ERCC1;PPP1R13L;CD3EAP
|
Adult Liver Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
The results of clinicopathologic analysis showed that A allele at the rs737241 locus could increase the expression level of AFP (P = .007), the rs1046282 mutation C allele could increase the AFP expression level (P = .011), rs4024 locus mutation A allele could reduce the risk of vascular invasion (P = .013), rs3212948 locus mutation T allele could reduce the differentiation of liver cancer (P = .022), rs1046282 locus C allele could reduce the DNA load of hepatitis B virus (P = .035), and rs735482 A allele could increase the tumor size in HCC (P = .037).The SNPs in rs737241 for AFP gene may correlate with the occurrence of HCC.
|
30946366 |
2019 |
|
rs1046282
|
ERCC1;PPP1R13L;CD3EAP
|
Liver and Intrahepatic Biliary Tract Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
The results of clinicopathologic analysis showed that A allele at the rs737241 locus could increase the expression level of AFP (P = .007), the rs1046282 mutation C allele could increase the AFP expression level (P = .011), rs4024 locus mutation A allele could reduce the risk of vascular invasion (P = .013), rs3212948 locus mutation T allele could reduce the differentiation of liver cancer (P = .022), rs1046282 locus C allele could reduce the DNA load of hepatitis B virus (P = .035), and rs735482 A allele could increase the tumor size in HCC (P = .037).The SNPs in rs737241 for AFP gene may correlate with the occurrence of HCC.
|
30946366 |
2019 |
|
rs1046282
|
ERCC1;PPP1R13L;CD3EAP
|
Malignant neoplasm of liver
|
|
0.010 |
GeneticVariation |
BEFREE |
The results of clinicopathologic analysis showed that A allele at the rs737241 locus could increase the expression level of AFP (P = .007), the rs1046282 mutation C allele could increase the AFP expression level (P = .011), rs4024 locus mutation A allele could reduce the risk of vascular invasion (P = .013), rs3212948 locus mutation T allele could reduce the differentiation of liver cancer (P = .022), rs1046282 locus C allele could reduce the DNA load of hepatitis B virus (P = .035), and rs735482 A allele could increase the tumor size in HCC (P = .037).The SNPs in rs737241 for AFP gene may correlate with the occurrence of HCC.
|
30946366 |
2019 |
|
rs1046282
|
ERCC1;PPP1R13L;CD3EAP
|
Liver carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
The results of clinicopathologic analysis showed that A allele at the rs737241 locus could increase the expression level of AFP (P = .007), the rs1046282 mutation C allele could increase the AFP expression level (P = .011), rs4024 locus mutation A allele could reduce the risk of vascular invasion (P = .013), rs3212948 locus mutation T allele could reduce the differentiation of liver cancer (P = .022), rs1046282 locus C allele could reduce the DNA load of hepatitis B virus (P = .035), and rs735482 A allele could increase the tumor size in HCC (P = .037).The SNPs in rs737241 for AFP gene may correlate with the occurrence of HCC.
|
30946366 |
2019 |
|
rs1046282
|
ERCC1;PPP1R13L;CD3EAP
|
Tumor Cell Invasion
|
|
0.010 |
GeneticVariation |
BEFREE |
The results of clinicopathologic analysis showed that A allele at the rs737241 locus could increase the expression level of AFP (P = .007), the rs1046282 mutation C allele could increase the AFP expression level (P = .011), rs4024 locus mutation A allele could reduce the risk of vascular invasion (P = .013), rs3212948 locus mutation T allele could reduce the differentiation of liver cancer (P = .022), rs1046282 locus C allele could reduce the DNA load of hepatitis B virus (P = .035), and rs735482 A allele could increase the tumor size in HCC (P = .037).The SNPs in rs737241 for AFP gene may correlate with the occurrence of HCC.
|
30946366 |
2019 |
|
rs1046282
|
ERCC1;PPP1R13L;CD3EAP
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
The haplotype ERCC2 rs3916874(G) and rs238415(C) [OR (95% CI)=1.26 (1.02-1.57), P=0.03] in block 1 and the haplotype PPP1R13L rs4803817(A), CD3EAP rs1046282(T), rs735482(C), ERCC1 rs3212980(A), rs3212964(G) [OR (95% CI)=3.56 (1.55-8.18), P=0.005] in block 3 were associated with lung cancer risk.
|
24140460 |
2013 |
|
rs3212986
|
ERCC1;CD3EAP
|
Glioma
|
|
0.070 |
GeneticVariation |
BEFREE |
ERCC1 rs3212986 is a common single nucleotide polymorphism and may contribute toward individual susceptibility for glioma.
|
26264164 |
2016 |
|
rs3212986
|
ERCC1;CD3EAP
|
Glioma
|
|
0.070 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that glioma susceptibility is associated with rs1799782 and rs25487 of X-ray repair complementing defective repair in Chinese hamster cells 1 (XRCC1), rs1805377 of XRCC4, rs1800067 of excision repair cross-complementing rodent repair deficiency complementation group 4 (ERCC4) and rs3212986 of ERCC1 in Asian population, and rs12917 of O-6-methylguanine-DNA methyltransferase (MGMT) and rs1136410 of poly(ADP-ribose) polymerase 1 (PARP1) in Caucasian population.
|
27055523 |
2017 |
|
rs3212986
|
ERCC1;CD3EAP
|
Glioma
|
|
0.070 |
GeneticVariation |
BEFREE |
Our meta-analysis indicated that the ERCC1 rs3212986 polymorphism and 2 polymorphisms in ERCC2 gene (rs13181 and rs1799793) contributed to the susceptibility of glioma.
|
28514298 |
2017 |
|
rs3212986
|
ERCC1;CD3EAP
|
Glioma
|
|
0.070 |
GeneticVariation |
BEFREE |
Genetic variants found in DNA repair genes (ERCC1, rs3212986; ERCC2, rs13181; ERCC4, rs1800067; ERCC5, rs17655; XRCC1, rs1799782, rs25487, rs25489; XRCC3, rs861539) have been reported to have an ambivalent association with the development of glioma.
|
26843108 |
2017 |
|
rs3212986
|
ERCC1;CD3EAP
|
Glioma
|
|
0.070 |
GeneticVariation |
BEFREE |
For ERCC1 C8092A (dbSNP: rs3212986, C>A), the combined results show that carriers of the AA genotype may be associated with a higher risk of adult glioma than carriers of the CA and CC genotypes.
|
24254311 |
2014 |
|
rs3212986
|
ERCC1;CD3EAP
|
Glioma
|
|
0.070 |
GeneticVariation |
BEFREE |
We found that SNPs rs3212986 (odds ratio [OR] = 1.35 (1.08-1.68), P = .008), rs13181 (OR = 1.18 (1.06-1.31), P = .002), and rs25487 (OR = 1.12 (1.03-1.22), P = .007) in DNA repair genes ERCC1, ERCC2 (XPD), and XRCC1 may increase the risk of glioma, while polymorphisms rs1136410 (OR = 0.78 (0.68-0.89), P = .0004) and rs12917 (OR = 0.84 (0.73-0.96), P = .01) in PARP1(ADPRT) and MGMT are associated with decreased susceptibility to glioma.
|
24500421 |
2014 |
|
rs3212986
|
ERCC1;CD3EAP
|
Glioma
|
|
0.070 |
GeneticVariation |
BEFREE |
Subgroup analysis showed that the ERCC1 rs3212986 AA genotype was significantly associated with an increased risk of glioma in the Chinese population (odds ratio = 1.37, 95% confidence interval = 1.07-1.55), but no association in Caucasian Chinese.
|
25867436 |
2015 |
|
rs3212986
|
ERCC1;CD3EAP
|
Colorectal Carcinoma
|
|
0.060 |
GeneticVariation |
BEFREE |
In this case-control study, ERCC1 rs11615 and rs3212986 genotypes and their interaction with consumption of cigarettes and alcohol in determining CRC risk were investigated among 362 CRC patients and 362 age- and gender-matched healthy controls.
|
28476796 |
2017 |
|
rs3212986
|
ERCC1;CD3EAP
|
Malignant neoplasm of stomach
|
|
0.060 |
GeneticVariation |
BEFREE |
Our meta-analysis indicated that the <i>ERCC1</i> rs3212986 A/C polymorphism was not associated with response to chemotherapy or overall survival time in GC.
|
29302191 |
2018 |
|
rs3212986
|
ERCC1;CD3EAP
|
Colorectal Carcinoma
|
|
0.060 |
GeneticVariation |
BEFREE |
Interestingly, an analysis combining both ERCC1 rs3212986 and MLH3 rs108621 also showed an increased risk of CRC.
|
29516665 |
2018 |
|
rs3212986
|
ERCC1;CD3EAP
|
Stomach Carcinoma
|
|
0.060 |
GeneticVariation |
BEFREE |
We conducted a prospective study to analyze whether ERCC1 rs11615 and rs3212986 and ERCC2 rs13181 and rs1799793 gene polymorphisms could serve as potential biomarkers for the prognosis of gastric cancer.
|
26823845 |
2015 |
|
rs3212986
|
ERCC1;CD3EAP
|
Colorectal Carcinoma
|
|
0.060 |
GeneticVariation |
BEFREE |
However, we did not observe any association between the colorectal cancer risk and the rs3212986(ERCC1) and rs17655(ERCC5) polymorphisms.
|
31568607 |
2019 |
|
rs3212986
|
ERCC1;CD3EAP
|
Stomach Carcinoma
|
|
0.060 |
GeneticVariation |
BEFREE |
We performed a study to investigate the role of ERCC1 (rs11615, rs2298881, and rs3212986) and ERCC2 (rs13181, rs238406, and rs1799793) polymorphisms in the prognosis of gastric cancer.
|
26782397 |
2015 |
|
rs3212986
|
ERCC1;CD3EAP
|
Non-Small Cell Lung Carcinoma
|
|
0.060 |
GeneticVariation |
BEFREE |
Compared with CC genotype, AA genotype of ERCC1 rs3212986 was a high-risk factor for NSCLC (OR = 3.246; 95%CI: 1.375-7.663).
|
30453383 |
2018 |
|
rs3212986
|
ERCC1;CD3EAP
|
Stomach Carcinoma
|
|
0.060 |
GeneticVariation |
BEFREE |
In conclusion, our finding suggests that ERCC1 rs3212986 and ERCC2 rs13181 gene polymorphism could influence the response to chemotherapy and clinical outcome of gastric cancer.
|
26191265 |
2015 |